Advances in Immunology, Vol. 69 by Frank J. Dixon

By Frank J. Dixon

The Scripps examine Institute, los angeles Jolla, CA. most up-to-date findings within the box of immunology. converted define layout.

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The second pathway is rearrangement independent and requires irradiation, not to induce a DNA damage response, but to mutationally inactivate p53 alleles in developmentally arrested thymocytes. For unknown reasons, inactivation of p53 then results in limited developmental progression to the DP stage. Although mutations in p53 are known to suppress apoptosis, it seems unlikely that such mutations can bring about differentiative signals. Therefore, the promoting effects of y irradiation or p53 deficiency on the differentiation of CD25+CD44-""" TN cells in RAG-'- mice could merely be a consequence of prolonged survival.

1996a). , 1996) provide an appealing argument in favor of a VpreT subunit, the difference between TCRP and IgH chains in terms of folding, as well as structural differences between pTa and A5 chains (reviewed in von Boehmer and Fehling, 1997), should also be considered. C. PRE-TCRFUNCTION IN EARLY THYMOCYTE DEVELOPMENT 1. , 1995a). Such animals were generated via gene targeting by deleting the two last exons of the pTa gene encoding the transmembrane region, the cytoplasmic tail, and the cysteine involved in heterodimer formation.

1994). Approximation of the modules within a single preTCWCD3 complex would then result in cross-phosphorylation of functional motifs, present in the cytoplasmic taiIs of these components. , 1994, 1996a). The ability of the CD3 complex to transduce TCR-derived signals depends on a shared functional sequence, the immunoreceptor tyrosinebased activation motif (ITAM), that is located within the intracellular portion of each CD3 component (reviewed by Weiss, 1993). Individual ITAMs consist of two Tyr-X-X Leu/Ile domains that are separated by six to eight X-type residues, where X denotes a nonconserved amino acid.

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