Advances in Cancer Research, Vol. 77 by George F. Vande Woude, George Klein

By George F. Vande Woude, George Klein

Advances in melanoma study offers beneficial info at the fascinating and fast-moving box of melanoma study. right here once more, impressive and unique reports are awarded. Key good points * The Yin Yang of TCF/b-Catenin Signalling * Biochemical and scientific Implications of the Erb/HER Signaling community of progress issue Receptors * p53 and Human melanoma: the 1st 10000 Mutations * Macrophage Stimulating Protein * CD44 Glycoproteins in Colorectal melanoma; Expression; functionality; and Prognostic price * an easy Modes for Carcinogenesis of Colorectal melanoma with Microsatellite Instability

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Advances in Cancer Research, Vol. 77

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2 Epithelial–mesenchymal interactions in the promotion of cancer. Cells of mesenchymal origin, embedded within the stroma, synthesize and secrete EGF-like growth factors. Diffusing through the basal lamina, surrounding glandular structures, the polypeptide ligands encounter binding receptors exposed on the surface of epithelial cells. The receptor repertoire of the cell can determine the biological response achieved by such interactions. Accordingly, high expression of ErbB-2 can contribute to the amplification of growth factor signaling, driving the cells toward a malignant phenotype.

1998). Bertheau et al. (1998) showed that the status of ErbB-2 was prognostic by the Cox model analysis in the younger patient cohort, under age 35, whereas p53 was prognostic in the age 36–50 group. , 1991). , 1998). , 1991). , 1990). These and other conflicting results may relate to the size of the population analyzed and to some technical considerations. Essentially, determination of positivity may vary, especially in earlier studies, with the type of analysis or the identity of antibody used for ErbB2 immunostaining.

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