A renascence of the Irish art of lace-making microform : by Alan S Cole

By Alan S Cole

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Extra info for A renascence of the Irish art of lace-making microform : Illustrated by photographic reproductions of Irish laces, made from new and specially designed patterns

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Project 3, "Modulation of Signal Transduction Pathways by Tea Components" will focus on mechanisms key? to the inhibition of cell transformation and apoptosis in cell lines by caffeine and polyphenols as well as their derivatives, using cell and molecular biology approaches. Facilitated by the "Tea Chemistry and Analysis Core" and "Administrative Core, "the three Projects are highly interactive and integrated. Jointly, we intend to make major contributions to the use of tea for the I chemoprevention of cancer.

The comparative studies (frog vs. mouse vs. fish) will permit an assessment of the role of RYR isoform variation in the Ca release process. Fast and slow fibers of mouse and "superfast" fibers of toadfish all have one major RYR isoform (denoted RYR1), whereas fast fibers of frog and fish have two isoforms (RyR1 and RyR3; found in similar proportion), and slow fibers of fish have a unique variant of RyR1 (termed RyR1slow). Functional comparisons among fibers having different isoform composition should yield important information regarding control and molecular adaptation of RYRs.

Increasing numbers of women are deferring childbearing to the later years. Since ovarian aging is accompanied by conception delay and an increased risk of infertility and trisomic conception, the identification of risk factors for accelerated ovarian aging would have significant implications for reproductive research and primary prevention. The proposed study draws on data from two already completed studies to identify risk factors for ovarian age. In the first study, ovarian age is measured by age at onset of the menopausal transition and at menopause in 494 women.

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